He plans to hold talks with Pakistani President Asif Ali Zardari, Prime Minister Yousuf Raza Gilani, army chief General Ashfaq Kayani and the head of the intelligence services, General Ahmad Shuja Pasha.
Holbrooke also plans to meet with representatives of those people displaced by fighting against Taliban militants in the northwest of the country.
State Department spokesperson Robert Wood told reporters that in Islamabad the envoy would also meet with citizens from Swat, Buner, Malakand, Peshawar, Dera Ismail Khan and South Waziristan, where Pakistani forces are mounting an offensive against insurgents.